#HRS2025 YIA Competition - Basic Science Finalists-#HRS2025 YIA Competition

Video Transcription

Video Summary

The Young Investigator Award Ceremony focused on the basic science part of the competition, with Ravi Ranjan representing the committee. Finalists presented their research, followed by a Q&A session with judges. The presentations delved into intricate cardiac-related studies: Lillian Gutierrez explored exercise-induced dysregulation in PKP2 arrhythmogenic cardiomyopathy, focusing on adrenergic response and calcium transient amplitude in myocytes. The second presentation by Christian Egli from Vanderbilt University highlighted the search for genotype-specific therapeutics for channelopathies using high-throughput screening methods. He identified AvaciaPib as a promising drug to improve trafficking and activate KV11.1 channels, potentially benefiting long QT syndrome patients. The final speaker, Saranda Nemanja from the University of Bern, discussed gene therapy in rabbits for Short QT1 syndrome, demonstrating that a suppression-replacement gene therapy can normalize QT interval and show efficacy at cellular and whole-heart levels. Each presentation contributed novel insights into addressing cardiac disorders via innovative therapeutic approaches, showcasing the intersection of basic science and potential clinical applications. The award winner will be announced in the next day's ceremony.

Keywords

Young Investigator Award

basic science

cardiac studies

PKP2 arrhythmogenic cardiomyopathy

channelopathies

AvaciaPib

long QT syndrome

gene therapy

therapeutic approaches