(FIT)-Module 4 Workshop 6: Electrocardiographic and Electrophysiological Correlations-Poole Case 1 Answer

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Video Summary

The correct answer is C, interaction with dabigatranetoxalate. Dronetarone does not contain iodine like amiodarone, so it does not cause hypothyroidism, invalidating Answer A. Rosuvastatin's primary clearance is through feces, so it does not significantly interact with dronetarone or dabigatran, which makes Answer B incorrect. Dabigatranetoxalate, a prodrug, is affected by p-glycoprotein for its absorption; however, once absorbed, it is not impacted by other substrates or inducers of p-glycoprotein, such as dronetarone, which rules out Answer D.

Keywords

Dronetarone

Dabigatranetoxalate

Drug Interaction

P-glycoprotein

Rosuvastatin