(FIT)-Module 4 Workshop 6: Electrocardiographic and Electrophysiological Correlations-Poole Case 2 Answer

Video Transcription

Video Summary

The answer is B. Rifampin is a first-line medication for tuberculosis. It has many potential drug interactions as an inducer of both P-glycoprotein and several of the CYP450 isozymes, including CYP3A4. When eating is extensively metabolized in the liver by CYP3A4 as an inducer, rifampin may reduce the drug concentration. Therefore, A is not correct. And answer C and D are incorrect. Atenolol is routinely cleared and not affected by rifampin. Should be noted that isoniazid can cause severe idiosyncratic hepatotoxicity and could therefore cause and affect drugs metabolized in the liver.

Keywords

Rifampin

Tuberculosis treatment

Drug interactions

CYP3A4 induction

Isoniazid hepatotoxicity