(FIT)-Module 4 Workshop 6: Electrocardiographic and Electrophysiological Correlations-Poole Case 3 Answer

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Video Summary

The correct answer is D, lithium, a monovalent cation used as a first-line treatment for bipolar depression, which blocks cardiac sodium channels and can reveal a type 1 Brugada syndrome ECG pattern. It has been linked to repolarization abnormalities and atrial fibrillation, observable even at therapeutic levels. A study shows sodium channel blockage increases with higher lithium chloride doses. Other options, such as sertraline (A), can prolong the QT interval, while clonazepam (B) is a liver-metabolized medication, and spironolactone (C) causes hyperkalemia but not a type 1 Brugada ECG pattern.

Keywords

Lithium

Brugada syndrome

Sodium channel blockage

Bipolar depression treatment

Atrial fibrillation