(FIT)-Module 4 Workshop 6: Electrocardiographic and Electrophysiological Correlations-Poole Case 7 Answer

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So, the correct answer is answer C. Unlike amiodarone, morphine does not need to be adjusted when prescribing dronetarone. Dronetarone can increase the concentration of dabigatran due to being an inhibitor of PGP. So, answer B is wrong. Similarly, dronetarone can increase apixaban concentration due to being both an inhibitor of CYP3A4 and PGP. Answer D. There is an interaction between dronetarone and digoxin via PGP and it is recommended to decrease the digoxin concentration by 30-50% or answer C, which is correct.

Keywords

dronedarone

morphine

amiodarone

drug interactions

PGP inhibitor