(FIT)-Module 4 Workshop 6: Electrocardiographic and Electrophysiological Correlations-Poole Case 8 Answer

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Video Summary

Quinidine effectively treats Brugada syndrome by blocking the transient outward potassium current (ITO), which aids its antiarrhythmic properties. It also prolongs ventricular refractoriness and exhibits an anti-cholinergic effect. Unlike some drugs that block late sodium channels for long QT3 syndrome, quinidine's mechanism in Brugada syndrome isn't through its class 1 antiarrhythmic properties. Instead, it can reverse type 1 Brugada ECG abnormalities, making it recommended for symptomatic Brugada patients. Prokinamide can unmask Brugada patterns for diagnostic purposes, but quinidine actively addresses the underlying ECG issues.

Keywords

Quinidine

Brugada syndrome

transient outward potassium current

antiarrhythmic

type 1 Brugada ECG