(FIT)-Module 4 Workshop 7: Electrocradiogrpahic and Electrophysiological Correlations, Atrial Fibrillation, Clinical Scenarios and Syndromes-Poole Case 1 Question

Video Transcription

Video Summary

The video discusses a clinical scenario involving a 51-year-old female with symptomatic paroxysmal atrial fibrillation. The patient's baseline ECG showed sinus rhythm with specific PR, QRS, and QTC intervals. After starting a new antiarrhythmic drug, she experienced worsened palpitations during activity, as recorded by a Holter monitor. The question presented asks which pharmacologic mechanism is likely responsible for her symptoms, offering options including blockade of rapid delayed rectifier currents, voltage-gated sodium channels, L-type calcium channels, and inhibition of the sodium-potassium ATPase pump.

Keywords

paroxysmal atrial fibrillation

antiarrhythmic drug

Holter monitor

pharmacologic mechanisms

electrocardiogram intervals