(FIT)-Module 4 Workshop 7: Electrocradiogrpahic and Electrophysiological Correlations, Atrial Fibrillation, Clinical Scenarios and Syndromes-Poole Case 5 Question

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A 61-year-old male with recurrent PAF, previously treated with flecainide, is now considering a change due to a coronary artery disease diagnosis and past stenting. With an LVEF of 48%, hypertension, COPD, and normal renal function, the patient needs an appropriate dofetilide dosing recommendation. The options are: A) Amiodarone, B) Dofetilide 250 mcg BID and stop hydrochlorothiazide, C) Dofetilide 500 mcg BID, or D) Catheter ablation. Considering the patient's cardiac and overall health profile, starting dofetilide at a reduced dosage alongside stopping hydrochlorothiazide is advised (option B).

Keywords

recurrent paroxysmal atrial fibrillation

dofetilide dosing

coronary artery disease

left ventricular ejection fraction 48%

hypertension and COPD