(FIT)-Module 4 Workshop 7: Electrocradiogrpahic and Electrophysiological Correlations, Atrial Fibrillation, Clinical Scenarios and Syndromes-Poole Case 8 Answer

Video Transcription

Video Summary

Lithium, a monovalent cation used to treat bipolar depression, blocks the cardiac sodium channel, potentially causing repolarization abnormalities, atrial fibrillation, and unmasking Bergada syndrome ECG pattern. Even therapeutic levels of lithium can have these effects. Sertraline, another medication, can prolong the QT interval and is rarely associated with sudden cardiac death. Nasopan, metabolized in the liver by CYP3A4, can be affected by CYP3A4 inhibitors or inducers. Spironolactone can lead to hyperkalemia, promoting arrhythmias. The specific effect of lithium is its sodium channel blocking effect. References are provided.

Keywords

Lithium

Cardiac sodium channel blockade

Atrial fibrillation

QT interval prolongation

Hyperkalemia