Bioelectronics & Cardiac Neuromodulation (Joint Session)-Bioelectronics & Cardiac Neuromodulation (Joint Session)

Video Transcription

Video Summary

In this comprehensive session, several advancements and perspectives in cardiovascular and neurological interventions were discussed. Dr. Murat Fadim from Duke University initiated the session by exploring baro-stimulation therapy, primarily used in cardiovascular diseases such as hypertension and heart failure. This therapy targets the baro-reflex mechanism within the carotid bulbs, which controls blood pressure and heart rate. Dr. Fadim highlighted how baro-reflex sensitivity decreases in heart failure patients, correlating with adverse outcomes, and detailed the approval and effectiveness of a device that targets this reflex.<br /><br />Dr. Igor Efimov introduced biodegradable electronics, showcasing a bioresorbable pacemaker smaller than a grain of rice. This device operates using transient electronics, either charged through an external RF source or using intrinsic biometals activated optically. He also explored their applications in cardiac and neural stimulation, particularly suggesting their potential in pediatric cardiac surgeries and for temporary cardiac support.<br /><br />Jason Bradfield presented renal denervation as a method for autonomic modulation to reduce arrhythmias. He reported that while renal denervation shows promise in reducing blood pressure and arrhythmia episodes, its full potential is yet untapped due to challenges in targeting precise nerve sites and varying patient responses.<br /><br />Finally, Dr. Peter Hanna elaborated on cervical vagal nerve stimulation, revealing its dual role. While initially associated with promoting atrial fibrillation due to enhanced neural dispersion, low-level stimulation was shown to reduce atrial and ventricular arrhythmias long-term, suggesting its remodeling benefit. This emphasizes the importance of selective stimulation strategies to enhance therapeutic efficacy in arrhythmia management.<br /><br />Overall, the session weaved through novel therapeutic interventions, encompassing device innovation, mechanical and electrical stimulation techniques, and their potential to reshape treatment paradigms in both cardiovascular and neurological fields.

Keywords

cardiovascular interventions

neurological interventions

baro-stimulation therapy

biodegradable electronics

bioresorbable pacemaker

renal denervation

autonomic modulation

vagal nerve stimulation

arrhythmia management

therapeutic interventions