EP Fellows Curriculum: Cellular Electrophysiology Made Ridiculously Clinical-EP Fellows Curriculum: Cellular Electrophysiology Made Ridiculously Clinical

EP Fellows Curriculum: Cellular Electrophysiology Made Ridiculously Clinical

Video Transcription

Video Summary

The talk discussed cellular electrophysiology and its clinical implications. The speaker focused on three major categories of arrhythmia formation: abnormal automaticity, triggered activity, and reentry. Abnormal automaticity is often seen in situations where the membrane potential is depolarized, such as ischemia or potassium imbalances. Triggered activity occurs through early afterdepolarizations (EADs) or delayed afterdepolarizations (DADs) , which can lead to spontaneous firing of an action potential. Reentry occurs when there is unidirectional block, slow conduction velocity, and a long enough path length for the signal to travel in a circle. The speaker also discussed the importance of considering use dependence when choosing medications for arrhythmia treatment. Additionally, he mentioned specific conditions and triggers for different types of arrhythmias, such as long QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT) . The talk emphasized the need to understand the underlying mechanisms of arrhythmias in order to better diagnose and treat them.

Keywords

cellular electrophysiology

clinical implications

arrhythmia formation

abnormal automaticity

triggered activity

reentry

ischemia

early afterdepolarizations

long QT syndrome

catecholaminergic polymorphic ventricular tachycardia