EP and the Unusual Cardiomyopathies-Electrical Propagation in the Cardiomyopathic Heart (Presenter: Igor R. Efimov, PhD, FHRS)

Electrical Propagation in the Cardiomyopathic Heart (Presenter: Igor R. Efimov, PhD, FHRS)

Video Transcription

Video Summary

In this video, Igor Efimov from George Washington University discusses electrical propagation in the cardiomyopathic heart. He presents data obtained from studying live human hearts and explores the fundamental mechanisms of ventricular fibrillation and ventricular tachycardia in the myopathic heart. Efimov explains that there are two major mechanisms currently proposed for these arrhythmias: single or finite number of reentrant rotors and multiple wavelets. He discusses the complexity of cardiomyopathic remodeling processes and how various genes are responsible for these arrhythmias. Efimov's research focuses on high-level processes in regulatory networks and the role of promoters and enhancers. He presents data from a study involving human hearts and demonstrates that arrhythmia can only be sustained if the tissue volume exceeds the volume of wavelength in a three-dimensional myocardium. The findings suggest that understanding transcriptome and promoter/enhancer control circuits could offer new avenues for therapeutic intervention.

Meta Tag

Lecture ID 6623

Location Room 203

Presenter Igor R. Efimov, PhD, FHRS

Role Invited Speaker

Session Date and Time May 09, 2019 1:30 PM - 3:00 PM

Session Number S-031

Keywords

electrical propagation

cardiomyopathic heart

ventricular fibrillation

ventricular tachycardia

arrhythmias

myopathic heart