EP on EP Episode 75: CPVT--Gene alteration therapy with Silvia G Priori, MD, PhD-EP on EP Episode 75: CPVT--Gene alteration therapy with Silvia G Priori, MD, PhD

EP on EP Episode 75: CPVT--Gene alteration therapy with Silvia G Priori, MD, PhD

Video Transcription

Video Summary

In this segment of EP on EP, Professor Sylvia Priori discusses her ongoing research on catecholaminergic polymorphic ventricular tachycardia (CPVT) and gene therapy. CPVT is a disease that can lead to sudden death in young adolescents and children. Professor Priori explains how her team identified the culprit gene for CPVT and the clinical manifestations of the disease. She also discusses current treatment options, such as beta blockers and flecainide, as well as the challenges in managing the disease. Professor Priori highlights the potential of gene therapy in providing a more permanent and radical solution for CPVT, and the progress made in preclinical models to test the efficacy and safety of this approach.

Keywords

catecholaminergic polymorphic ventricular tachycardia

gene therapy

sudden death

beta blockers

flecainide