EP on EP Episode 90: Genetics of AF with Mina Chung, MD, FHRS-EP on EP Episode 90: Genetics of AF with Mina Chung, MD, FHRS

EP on EP Episode 90: Genetics of AF with Mina Chung, MD, FHRS

Video Transcription

Video Summary

In this video, Dr. Mina Chung discusses the role of genomics in atrial fibrillation (AFib). She explains that a careful history can often reveal a familial association with AFib, and that there are over a couple hundred loci on the DNA associated with the condition. One interesting finding is that a gene called PITX2, expressed in the left atrium, may suppress a left atrial sinus node program and contribute to AFib. Dr. Chung also discusses ongoing clinical trials, such as the TRMM-AF trial, which aims to investigate the effects of lifestyle modifications and a drug called metformin on AFib. She also touches on the topic of pulmonary veins and the need for atrial ablation in AFib treatment.

Keywords

genomics

atrial fibrillation

PITX2 gene

clinical trials

metformin