Everything We Know (or don't know) About LV Non-compaction-Everything We Know (or don't know) About LV Non-compaction

Video Transcription

Video Summary

The session at HRS 2025 focused on Left Ventricular Non-Compaction (LVNC) and included detailed discussions on the condition's genetics, imaging, and clinical management. The event began with an introduction to the genetic aspect by Lisa De La Fave-Castillo from Northwestern University, highlighting the complex inheritance patterns and genetic testing guidelines for cardiomyopathies linked to LVNC. Emphasis was placed on thorough family history assessments to identify genetic predispositions.<br /><br />Shiraz Muscati from Stanford University discussed imaging techniques, emphasizing the limitations of current diagnostic criteria, which are based on small patient cohorts. The importance of clinical context in diagnosis was stressed, noting the limitations of solely relying on imaging due to high false-positive rates in healthy individuals.<br /><br />The session concluded with Massimo Silvetti discussing clinical management strategies for LVNC in children, focusing on the variability in symptoms ranging from asymptomatic to severe conditions. Treatment strategies include medical management, ablation, and device implantation, like pacemakers and ICDs, tailored to the phenotype.<br /><br />Audience questions addressed genetic testing in neonates, anticoagulation practices, and primary prevention ICD guidelines, highlighting the challenges and importance of integrating clinical, genetic, and imaging data in managing LVNC. The panel stressed the need for continued research and refinement of diagnostic and management protocols for LVNC due to its complex nature and varied presentations.

Keywords

Left Ventricular Non-Compaction

LVNC

genetics

imaging

clinical management

cardiomyopathies

diagnostic criteria

treatment strategies

genetic testing

device implantation