Evolving Strategies in CCM® Therapy: Clinical Applications and Practical Approaches-Evolving Strategies in CCM® Therapy: Clinical Applications and Practical Approaches

Video Transcription

Video Summary

In a session on Cardiac Contractility Modulation (CCM) Therapy, Dr. Brad Knight and his colleagues discussed the integration and benefits of CCM for heart failure patients. Several key points emerged:

1. <strong>CCM Therapy Overview</strong>: Dr. Murat Fudim explained CCM as a device-based therapy delivering high-energy impulses to enhance cardiac function in heart failure patients with reduced ejection fraction (25% to 45%). This therapy is intended for patients who aren't responding well to conventional treatment or are ineligible for CRT.

2. <strong>Patient Selection and Timing</strong>: Discussions emphasized the need to evaluate patient symptoms closely, such as quality of life and daily functional capacity, rather than just relying on clinical trial metrics like mortality and hospitalization rates. Early administration of device therapy alongside GDMT (Guideline-Directed Medical Therapy) is advocated to optimize patient outcomes.

3. <strong>Real-world Efficacy and Trials</strong>: Data from real-world settings and ongoing trials, including in patients with preserved ejection fraction, support CCM's efficacy in reducing heart failure symptoms and hospitalizations. Integrating CCM in heart failure management is crucial, given its notable quality of life improvements.

4. <strong>Clinical Experience and Case Studies</strong>: Dr. Ambrose Panico shared personal experiences indicating that patients show significant symptomatic improvement post-CCM implantation. Physicians are encouraged to consider CCM early and not delay treatment until severe symptoms or disease progression.

Overall, the session highlighted CCM as an effective adjunctive therapy in the heart failure treatment paradigm, which should be incorporated earlier in patient management to enhance quality of life and potentially reduce mortality and hospitalization.

Keywords

Cardiac Contractility Modulation

CCM Therapy

heart failure

ejection fraction

patient selection

quality of life

real-world efficacy

clinical experience

Guideline-Directed Medical Therapy