HRS Board Review 2025 New Courses (Reviewers Copy)-Workshop 1_Electrocardio_London_2025

Workshop 1_Electrocardio_London_2025_case 7 answer

Video Transcription

Video Summary

Stefan experienced a cardiac arrest due to acquired long QT syndrome, with a QTC over 800 milliseconds, influenced by hypokalemia and antibiotics (fluconazole, levofloxacin, metronidazole). A month later, his QTC normalized off drugs, indicating acquired rather than inherited long QT syndrome, negating the need for genetic testing. This syndrome often results from drugs affecting the HERG potassium channel, reducing repolarization reserve. Up to 2% of people could develop it if given the right drug. Stefan should avoid QT-prolonging drugs, and resources are available to identify them.

Keywords

cardiac arrest

long QT syndrome

hypokalemia

HERG potassium channel

QT-prolonging drugs