My name is Dr. Barry London. I'm the Director of the Division of Cardiovascular Medicine and the Director of the Abood Cardiovascular Research Center at the University of Iowa in Iowa City. The title is workshop number 1, electrocardiographic electrophysiology correlations. We'll be presenting 10 cases today. I have no significant disclosures aside from receiving research funding from the NIH. We'll start with the first case. CV is a 54-year-old man with no history of palpitations, syncope, or neosyncope. He's on no medicines. His father had a cardiac arrest while undergoing chemotherapy. Genetic testing of his father showed a pathologic mutation in KCNQ1, a change of arginine to cysteine, that was present in both his dad and CV. This mutation has been identified in multiple Long QT syndrome patients. It has co-segregated in a large family with Long QT syndrome and was identified as a de novo mutation in a patient whose parents were negative for the mutation. This is CV's baseline electrocardiogram. This is his electrocardiogram two minutes into recovery after a stress, a treadmill stress test. Which of the following statements related to this case are true? A, CV has Long QT syndrome type 3 or LQT3. B, the exercise stress test is useful for the diagnosis of both Long QT syndrome type 1 and type 2. C, CV does not clinically have Long QT syndrome, and this is an example of incomplete penetrance. D, there is no lulfanadolol in the absence of symptoms.

Long QT syndrome

KCNQ1 mutation

electrocardiographic correlations

genetic testing

exercise stress tests