HRS Board Review 2025 New Courses (Reviewers Copy)-Workshop 1_Tomaselli_2025

Workshop 1_Tomaselli_2025_case 2 answer

Video Transcription

Video Summary

The ECG displays a type 1 Brugada pattern characterized by coved ST-segment elevation with T-wave inversion in the right precordial lead. This results from differences in phase 1 of the action potential across the right ventricular wall, attributed to variations in the transient outward potassium currents. These currents are more pronounced in the epicardium than the endocardium. While some with Brugada syndrome have sodium channel mutations, they don't create this current gradient, nor do calcium channel mutations. Inward rectifier currents affect resting membrane potential and later action potential phases.

Keywords

Brugada pattern

ST-segment elevation

potassium currents

sodium channel mutations

action potential