false
OasisLMS
Catalog
HRS Board Review 2025 New Courses (Reviewers Copy)
Workshop 1_Tomaselli_2025_case 5 answer
Workshop 1_Tomaselli_2025_case 5 answer
[Please upgrade your browser to play this video content]
Video Transcription
Video Summary
Adenosine activation of A1 receptors is the correct answer for affecting cardiac electrophysiology, causing a more negative maximal diastolic potential, slowing phase IV diastolic depolarization, and shortening the action potential duration. These effects occur via direct activation of G-protein coupled adenosine receptors and IKACH, leading to potassium channel opening and hyperpolarization. Indirectly, adenosine inhibits adenylyl cyclase, resulting in anti-adrenergic effects and reduced calcium current. Adenosine's impact can be altered by blocking its transport with dipyridamole or its receptors with methylxanthines, affecting heart rhythm management.
Keywords
Adenosine
Cardiac electrophysiology
G-protein coupled receptors
IKACH
Hyperpolarization
×
Please select your language
1
English