HRS Board Review 2025 New Courses (Reviewers Copy)-Workshop 1_Tomaselli_2025

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Video Summary

The case involves drug-induced QT prolongation, specifically linked to methadone use, leading to repetitive polymorphic ventricular tachycardia (VT). The electrocardiogram shows QT interval prolongation with abnormal STT waves. Although other conditions, such as ischemia or hypokalemia, were considered, they seem less likely due to mild presenting features. Methadone withdrawal significantly shortens the QT interval, indicating drug-induced long QT syndrome. Despite the possibility of a KCNH2 mutation, the primary issue appears to be methadone-induced QT interval prolongation, resulting in polymorphic VT.

Keywords

methadone

QT prolongation

ventricular tachycardia

electrocardiogram

long QT syndrome