Hypertrophic Cardiomyopathy: EP Considerations-Impact of Lifestyle and Genetics on Adverse Arrhythmia Outcomes in HCM (Presenter: Mark S. Link, MD, FHRS)

Impact of Lifestyle and Genetics on Adverse Arrhythmia Outcomes in HCM (Presenter: Mark S. Link, MD, FHRS)

Video Transcription

Video Summary

Genetic testing can be useful in hypertrophic cardiomyopathy (HCM) for family screening and cascade screening. If a proband tests positive for a genetic mutation, their next of kin can be tested. If they do not have the mutation, they do not need to undergo family screening. Around 50% of individuals with familial HCM have a pathogenic genetic mutation. Genetic testing can also be used for prognosis and preimplantation genetic diagnosis. However, the use of genetic testing to correct pathogenic genes in embryos is still a far-fetched concept. Regarding exercise, patients with HCM often exercise less than those without the condition due to fears about its use in this population. The benefits of exercise, such as reducing the risk of metabolic syndrome, obesity, hypertension, and mortality, are well known. However, there is also a potential for exercise to be an adverse remodeler of underlying cardiac disease and a trigger for sudden cardiac death. Current guidelines recommend low to moderate intensity exercise for patients with HCM, but there is limited evidence on the use of high-intensity exercise. Patients with HCM and implantable cardioverter-defibrillators (ICDs) should be cautious about engaging in physical activity as it may trigger ventricular arrhythmias. Shared decision-making is crucial when considering the risk and benefits of exercise in these patients.

Meta Tag

Lecture ID 16208

Location Room 152

Presenter Mark S. Link, MD, FHRS

Role Invited Speaker

Session Date and Time May 09, 2019 10:30 AM - 12:00 PM

Session Number S-012

Keywords

Genetic testing

hypertrophic cardiomyopathy

family screening

exercise

implantable cardioverter-defibrillators