Inherited and infectious Cardiomyopathies in Africa: Prevalence and Management-Inherited and infectious Cardiomyopathies in Africa: Prevalence and Management

Video Transcription

Video Summary

In this comprehensive session, several experts, including Dr. Ashley Chin and Professor Mavad, presented insights into the diagnosis, management, and research developments concerning inherited arrhythmogenic cardiomyopathy and associated conditions within Africa. Dr. Ashley Chin shared findings from South Africa's ARVC registry and the Imhotep registry, revealing similarities in ARVC presentation in South Africa to other global datasets and the significant role of genetics, particularly the PKP2 mutations. He discussed the journey of the ARVC registry initially established in 2003, highlighting its development and the critical role of genetic insights in understanding disease patterns, including novel mutations with potential founder effects traced to European ancestry.<br /><br />Professor Mavad provided an in-depth look at the management of inherited cardiomyopathy utilizing limited resources in Egypt, demonstrating the practical challenges faced, including resource limitations and the necessity to work with available tools like echocardiography due to the scarcity of cardiac MRIs and genetic testing. She showcased individual case studies, illustrating complex clinical scenarios and how they were navigated in real-time, highlighting both the challenges and innovative solutions adopted to manage such patients effectively with existing constraints.<br /><br />The session emphasized the importance of multidisciplinary collaboration, registry development, and the use of available interventions, including medical and device-based therapies, to manage and improve patient outcomes. There were calls for increased genetic research capabilities, better imaging resources, and collaboration across Africa to address these challenges more comprehensively, while raising awareness and advocating for more resources and support within these regions.

Keywords

inherited arrhythmogenic cardiomyopathy

ARVC registry

PKP2 mutations

genetic insights

South Africa

Egypt

multidisciplinary collaboration

resource limitations

genetic research

Africa