Late-Breaking Clinical Trials and Science: Clinical Trials Updates and Registries-Late-Breaking Clinical Trials and Science: Clinical Trials Updates and Registries

Video Transcription

Video Summary

The Heart Rhythm TV session highlighted several key late-breaking clinical trials and updates. The discussion opened with an emphasis on two key CIED trials, specifically the Protherian XL Trial, which extended the follow-up for patients using a Subcutaneous Implantable Cardioverter Defibrillator (SICD) versus Transvenous ICD to eight years. The trial aimed to assess complications and efficacy, finding the SICD non-inferior for long-term use compared to transvenous ICDs, with fewer lead-related complications associated with the SICD. Another pivotal study, the LEADER trial, investigated the outcomes of the small caliber ICD lead designed for left bundle branch area pacing, showcasing promising defibrillation efficacy and stable lead performance.<br /><br />TRANSFORM-AF addressed metabolic therapy's role in atrial fibrillation (AF) management, specifically using GLP-1 agonists like Ozempic to reduce recurrence rates, notably in patients with obesity. Results indicated a 13% reduction in AF events, prompting calls for further research into the pharmacological treatment of AF.<br /><br />The Casper Registry also featured prominently, examining unexplained cardiac arrest and emphasizing ongoing reevaluation and phenotyping in patients to improve diagnosis accuracy, showing a 43% diagnosis rate over long-term follow-up.<br /><br />The session's overarching theme focused on innovative approaches and ongoing trials exploring new device technologies and pharmacological therapies for cardiac conditions, highlighting the importance of continuous, rigorous follow-up and reassessment in clinical care. The discussions underscored an evolving landscape in arrhythmia management, with novel therapies and technological advancements shaping future practices.

Keywords

Heart Rhythm TV

clinical trials

Protherian XL Trial

Subcutaneous Implantable Cardioverter Defibrillator

Transvenous ICD

LEADER trial

left bundle branch area pacing

TRANSFORM-AF

GLP-1 agonists

Casper Registry

arrhythmia management