Mechanisms of Neuromodulation and Cardioneuroablation-Mechanisms of Neuromodulation and Cardioneuroablation

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Video Summary

The session at San Diego titled "Harlem 2025" featured a series of expert presentations on autonomic nervous system biomarkers and cardiac neuromodulation. Dr. Neil Herring kicked off with insights on the autonomic nervous system, emphasizing its complexity beyond just being an accelerator (sympathetic) or brake (parasympathetic). He highlighted the feedback loops involving ganglionic plexi and the brainstem, mentioning the late Jeffrey Ardell's contribution to this field.<br /><br />Herring explored biomarkers' challenges and benefits, such as heart rate variability and plasma catecholamines. He discussed neuropeptide Y as a promising biomarker linked to mortality in myocardial infarction and heart failure, with ongoing research potentially leading to new treatments beyond beta-blockers.<br /><br />Subsequent presentations by Dr. Alex Tan, Dr. Olujimi Ajijola, and Dr. Stavros Drakos delved into the modulation of the cardiac intrinsic autonomic nervous system. Tan presented on ganglionated plexi's anatomical and physiological roles, highlighting its contribution to arrhythmic triggers and treatments through ablation, drugs, and interventions like tragus stimulation. Ajijola's talk focused on how cardiac sympathetic denervation could reduce arrhythmic burden and even impact anxiety in humans. His animal studies shed light on the potential enceolytic effects of denervation.<br /><br />Drakos concluded with research on vagal nerve stimulation's promise in reducing inflammation linked to conditions like heart failure with preserved ejection fraction (HFpEF), emphasizing the neuro-immune axis. His studies indicate that targeted neuropeptide modulation could serve as a future therapeutic target.<br /><br />The moderators praised the session's insights, hinting at future developments in personalized and technology-driven neuromodulation therapies.

Keywords

Harlem 2025

autonomic nervous system

cardiac neuromodulation

biomarkers

heart rate variability

neuropeptide Y

ganglionated plexi

cardiac sympathetic denervation

vagal nerve stimulation

neuro-immune axis