Neuromodulation of Arrhythmias – Theory and Practice-Neuromodulation of Arrhythmias

Video Transcription

Video Summary

In this video, Dr. Olu Adujola from the UCLA Cardiac Arrhythmias Center discusses the theory and practice of neuromodulation for ventricular arrhythmias. He highlights the importance of neuromodulation for therapy and presents a case study of a patient with ventricular tachycardia. Dr. Adujola explains that the heart is densely innervated with nerves and neurons, which control its function through feedback loops. In cases of disease, such as chronic cardiac injury, there is intense remodeling of the nervous system, leading to altered neurotransmission and increased sympathetic drive to the heart. This remodeling extends from the peripheral nervous system to the brain, affecting the insula cortex. Dr. Adujola emphasizes the importance of neural remodeling for clinical outcomes and presents neuropeptide Y as an example. He discusses various approaches to neuromodulation, including thoracic epidural anesthesia, stellate ganglion block, cardiac sympathetic denervation, renal denervation, transcranial magnetic stimulation, tragus stimulation, and vagus nerve stimulation. Dr. Adujola provides evidence from studies investigating the efficacy of these techniques in suppressing ventricular arrhythmias. He concludes by highlighting the importance of early application of neuromodulation and the establishment of comprehensive neurocardiology programs.

Keywords

neuromodulation

ventricular arrhythmias

theory and practice

neuromodulation therapy

case study

neural remodeling

neuromodulation techniques

comprehensive neurocardiology programs