Optimizing Genotype-informed Approaches for Arrhythmogenic Cardiomyopathies – The Latest in Genetic Testing, Risk Stratification, and Exercise (Joint Session)-Optimizing Genotype-informed Approaches for Arrhythmogenic Cardiomyopathies – The Latest in Genetic Testing, Risk Stratification, and Exercise (Joint Session)

Optimizing Genotype-informed Approaches for Arrhythmogenic Cardiomyopathies – The Latest in Genetic Testing, Risk Stratification, and Exercise (Joint Session)

Video Transcription

Video Summary

The transcript covers a session held during the Heart Rhythm 2025 event, focusing on genetic counsel and testing strategies related to arrhythmogenic cardiomyopathies (ACMs). The session, led by experts including Brittany Murray, Dr. Julia Catran-Turini, Dr. James Daubert, and Dr. Jody Ingalls, explored various aspects of genetic testing and its implications.<br /><br />Brittany Murray discussed the importance of genetic testing in ACMs, emphasizing its standard care status and broader application beyond individuals meeting traditional diagnostic criteria. She highlighted a critical view of genetic reports, advocating for specialized interpretation to ensure accurate diagnosis and treatment. This includes cases where genetic findings do not align neatly with family histories or phenotypes.<br /><br />Dr. Julia Catran-Turini focused on genotype and phenotype roles in risk stratification and ICD implantation, illustrating how gene-specific data can refine predictions. Notably, she points out that different genes like Desmoplakien may necessitate unique risk models.<br /><br />Dr. James Daubert addressed the impact of exercise on ACMs, drawing correlations between high physical activity and disease exacerbation in certain genetic cases. His analysis underlined the need for tailored exercise guidance depending on genetic predisposition.<br /><br />Dr. Jody Ingalls concluded with a historical overview of genetic testing for cardiovascular diseases and highlighted current challenges, including variant interpretation and the importance of considering ancestry. She stressed the need for improvements in genetic testing accessibility and the equitable distribution of benefits across diverse populations. <br /><br />This session encapsulates the evolving landscape of genetic testing in cardiomyopathy, aiming to optimize patient management and family counseling through personalized approaches.

Keywords

Heart Rhythm 2025

genetic testing

arrhythmogenic cardiomyopathies

Brittany Murray

risk stratification

genotype-phenotype

exercise impact

ICD implantation

variant interpretation

personalized medicine