Session IV: Noninvasive Diagnosis and Treatment-6156-Antiarrhythmic Drugs Part I

Video Transcription

Video Summary

In this presentation, Jeannie Poole discusses the mechanism of action, clinical indications and use, metabolism, and drug-drug interactions of antiarrhythmic drugs. She begins by explaining the Vaughn-Williams classification, which categorizes drugs based on their primary mechanism of action. Class one drugs, including quinidine, procainamide, and disopiramide, act on the sodium channels, while class two drugs, such as beta blockers, act on the beta receptors. Class three drugs, like amiodarone and sotalol, block potassium channels, and class four drugs, such as calcium channel blockers, block calcium channels. She also discusses the effects of these drugs on the action potential. Class one drugs reduce phase zero slope and the peak of the action potential, while class three drugs delay phase three repolarization, increasing the action potential duration. Poole discusses specific drugs within each class, their indications, and notable adverse effects. She highlights the importance of considerations such as first-pass metabolism, genetic polymorphisms, and drug-drug interactions in the pharmacokinetics of antiarrhythmic drugs. Finally, she explains concepts such as half-life, steady state, and drug clearance.

Keywords

antiarrhythmic drugs

mechanism of action

clinical indications

metabolism

drug-drug interactions

Vaughn-Williams classification

sodium channels

beta receptors