The Diverse Roles of Inflammation in Arrhythmogenesis-The Diverse Roles of Inflammation in Arrhythmogenesis

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Video Summary

The session, co-chaired by Peter Hanna from UCLA and Nick Moisea from Ohio State University, focused on the diverse roles of inflammation in arrhythmogenesis, featuring four expert speakers. Dr. Giovanni Pareto discussed myocardial inflammation's relevance beyond acute viral or autoimmune myocarditis, highlighting its overlap with genetic cardiomyopathies and identified two main mechanisms of arrhythmias: non-ischemic scar and impaired cell connections. He emphasized the potential of targeting inflammation with treatments such as the IL-1 axis blockade to modify arrhythmic outcomes.<br /><br />Dr. Sharon George presented on cardiac electrophysiology changes induced by the chemotherapy drug doxorubicin, demonstrating sex-specific alterations, especially in females. Her studies emphasized the role of potassium channels during early repolarization phases and cytokine modulation like TIMP-1, which could influence ion channel expression.<br /><br />Dr. Jin Lee focused on autoantibodies' role in arrhythmias, such as antibodies targeting ion channels like KCNQ1 associated with shorter QT intervals, and Cav1.2 in ventricular fibrillation. He also explored newly identified biomarkers for sudden infant death syndrome (SIDS) using TRPV2 antibodies, suggesting a potential autoimmune contribution.<br /><br />Lastly, Dr. Budadip Dhan reviewed the influence of T-cells in arrhythmogenesis, noting their role in electrical and structural remodeling of the heart. T-cell interaction with the myocardium and other immune cells contributes to arrhythmias in contexts like atrial fibrillation, ventricular arrhythmias, and myocarditis, emphasizing the complexity of immune involvement in heart rhythm disorders.<br /><br />The session closed with a discussion of future directions in understanding immune mechanisms and potential therapeutic targets for arrhythmias.

Keywords

inflammation

arrhythmogenesis

myocardial

cardiac electrophysiology

autoantibodies

T-cells

arrhythmias

immune mechanisms

therapeutic targets

cytokine modulation