The Lead Episode 108: LIVE from Heart Rhythm 2025 in San Diego, A Discussion of Left Bundle Branch Area Pacing Compared to Biventricular Pacing in Candidates for Cardiac Resynchronization Therapy (LVEF <50%): Results from International Collaborative LBBAP Study (I-CLAS)-The Lead Episode 108 (video)

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Video Summary

A recent discussion from the Heart Rhythm Sessions in San Diego focused on a study comparing left bundle branch area pacing (LBBAP) with biventricular (BiV) pacing for cardiac resynchronization therapy (CRT) in patients with ejection fractions under 50%. The study, part of the iClass investigation, showed LBBAP had a lower composite endpoint of heart failure hospitalizations and mortality compared to CRT, driven mainly by reduced hospitalizations. Although promising, experts noted it remains observational and anticipates further validation from a randomized trial. While LBBAP gains traction, CRT remains a viable option, with diverse approaches in practice.

Keywords

LBBAP

biventricular pacing

cardiac resynchronization therapy

heart failure hospitalizations

iClass investigation