The Lead Episode 110: A Discussion of Left Bundle Branch Area Pacing in Hypertrophied Hearts: The Ex-Vivo Ovine Model to Study Deployment of Pacing Leads in Thick Septum LIVE from Heart Rhythm 2025 in San Diego-The Lead Episode 110 (video)

Video Transcription

Video Summary

In a recent live podcast from HRS 2025, an animal study explored lead biomechanics in hypertrophied hearts, specifically examining left bundle branch area pacing. Dr. Parikshik Sharma discussed the investigation using 25 hypertrophied bovine hearts and various pacing leads. The study aimed to understand challenges in lead delivery into thick septa, finding that stylet-driven leads offered superior septal penetration compared to luminless leads, overcoming myocardial barriers more effectively. The insights may guide future clinical practice, although larger, randomized controlled trials are needed to confirm these findings in human patients.

Keywords

lead biomechanics

hypertrophied hearts

left bundle branch area pacing

stylet-driven leads

clinical practice