The Lead Episode 112: A Discussion of Brugada Syndrome Ablation for the Prevention of VS Episodes (BRAVE) LIVE from Heart Rhythm 2025 in San Diego-The Lead Episode 112 Speaker Information

The Lead Episode 112 Speaker Information

Pdf Summary

The discussion centers on the article "Brugada Syndrome Ablation for the Prevention of Ventricular Fibrillation Episodes (BRAVE)," published in the Heart Rhythm Journal. The study, authored by a multidisciplinary team led by Koonlawee Nademanee, MD, FHRS, explores the use of catheter ablation as a therapeutic strategy to prevent ventricular fibrillation episodes in patients with Brugada Syndrome, an inherited arrhythmia condition associated with sudden cardiac death.<br /><br />The session is hosted by Jason T. Jacobson, MD, FHRS, from Westchester Medical Center and New York Medical College, with contributions from experts Maynak Sardana, MBBS, MS (Mayo Clinic Arizona), and Marmar Vaseghi, MD, MS, PhD, FHRS (University of California, Los Angeles). These clinicians provide clinical insights and discuss the impact of the BRAVE study on current management paradigms.<br /><br />Disclosures note that Dr. Jacobson has consulting roles and research interests with several medical device and biotechnology companies, while Dr. Sardana declares no conflicts. The discussion highlights the potential benefit of targeted epicardial ablation in reducing the incidence of life-threatening ventricular fibrillation episodes in Brugada patients, emphasizing improvements in procedural approaches and patient outcomes. The multidisciplinary panel underscores the importance of this advancing treatment modality in high-risk patients and identifies ongoing research needs to optimize patient selection and long-term efficacy.<br /><br />Overall, the BRAVE study presents significant evidence supporting ablation therapy as a preventive measure against recurrent ventricular fibrillation episodes in Brugada Syndrome, marking a potential shift in treatment strategies beyond implantable cardioverter-defibrillator (ICD) reliance.

Keywords

Brugada Syndrome

ventricular fibrillation

catheter ablation

BRAVE study

sudden cardiac death

epicardial ablation

implantable cardioverter-defibrillator

arrhythmia management

multidisciplinary team

patient outcomes