The Lead Episode 113: A Discussion on the Effect of Pulsed-Field Ablation on Human Coronary Arteries: A Longitudinal Study With Intracoronary Imaging LIVE from Heart Rhythm 2025 in San Diego-The Lead Episode 113 Speaker Information

The Lead Episode 113 Speaker Information

Pdf Summary

This discussion centers on the article titled "Effect of Pulsed-Field Ablation on Human Coronary Arteries: A Longitudinal Study With Intracoronary Imaging," published in JACC: Clinical Electrophysiology. The study, conducted by Tam et al., investigates the impact of pulsed-field ablation (PFA) on human coronary arteries, using longitudinal intracoronary imaging to provide detailed vascular insights.<br /><br />The session was hosted by Dr. Michael S. Lloyd of Emory University, with contributions from Dr. Emily P. Zeitler of Dartmouth Health and Dr. Stephanie Wang of SSM St. Mary's - Madison. The panel brought expertise in cardiac electrophysiology and clinical research.<br /><br />Pulsed-field ablation is an evolving technique in cardiac electrophysiology, offering a potentially safer alternative to traditional thermal ablation methods by selectively targeting myocardial tissue while sparing adjacent structures such as coronary arteries. This study focuses on confirming the safety profile of PFA concerning coronary artery integrity, a crucial factor in its clinical adoption.<br /><br />Disclosures were noted, with Dr. Zeitler and Dr. Lloyd reporting various consultancy and speaking relationships with medical device and pharmaceutical companies, while Dr. Wang had no disclosures.<br /><br />Overall, the discussion highlights the importance of intracoronary imaging in monitoring vascular responses post-PFA and adds to the growing evidence supporting PFA’s safety for coronary arteries. The insights from this longitudinal study aim to guide clinicians in optimizing ablation strategies and advancing patient outcomes in arrhythmia management.

Keywords

Pulsed-Field Ablation

Human Coronary Arteries

Longitudinal Study

Intracoronary Imaging

Cardiac Electrophysiology

Safety Profile

Myocardial Tissue

Thermal Ablation Alternatives

Arrhythmia Management

Vascular Response