The Lead Episode 113: A Discussion on the Effect of Pulsed-Field Ablation on Human Coronary Arteries: A Longitudinal Study With Intracoronary Imaging LIVE from Heart Rhythm 2025 in San Diego-The Lead Episode 113 (video)

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Video Summary

A recent live San Diego study examined the effects of pulse field ablation (PFA) on human coronary arteries, focusing on coronary spasm and vessel changes immediately and three months post-ablation. Using coronary angiograms and OCT scans, researchers observed nearly 50% of vessels showed severe vasospasm during CTI ablation, despite nitroglycerin use. At three months, mild but variable lumen narrowing and increased wall thickness were noted, with uncertain long-term consequences. Clinicians expressed caution using PFA near coronary arteries, especially in patients with existing coronary disease, recommending informed patient discussions and considering alternative ablation methods until further data emerge.

Keywords

pulse field ablation

coronary arteries

vasospasm

coronary angiograms

lumen narrowing