The Lead Episode 124: A Discussion of Catheter Ablation vs Lifestyle Modification With Antiarrhythmic Drugs to Treat Atrial Fibrillation: PRAGUE 25 Trial, LIVE at HRX-A Discussion of Catheter Ablation vs Lifestyle Modification With Antiarrhythmic Drugs to Treat Atrial Fibrillation: PRAGUE 25 Trial, LIVE at HRX (Speaker Information)

A Discussion of Catheter Ablation vs Lifestyle Modification With Antiarrhythmic Drugs to Treat Atrial Fibrillation: PRAGUE 25 Trial, LIVE at HRX (Speaker Information)

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The PRAGUE-25 trial, discussed in a session hosted by Dr. Danesh Kella (Mayo Clinic, Florida) and featuring experts Dr. Prashanthan Sanders (University of Adelaide) and Dr. Ratika Parkash (QEII Health Sciences Center), compares catheter ablation versus lifestyle modification combined with antiarrhythmic drugs for treating atrial fibrillation (AF). Published in JACC by Pavel Osmancik and colleagues, the trial evaluates the relative benefits and outcomes of these two treatment strategies.<br /><br />Catheter ablation is a minimally invasive procedure that targets irregular electrical pathways causing AF, aiming to restore normal heart rhythm. Conversely, lifestyle modification with antiarrhythmic drugs focuses on managing risk factors such as weight, physical activity, and comorbidities alongside pharmacotherapy to maintain rhythm control.<br /><br />The discussion highlights the trial's methodology, patient populations, and endpoints, providing insight into the efficacy and safety profiles of both approaches. Experts debated the balance between procedural risks of ablation versus the chronic management and side effects related to drug therapy and lifestyle changes.<br /><br />Disclosures noted involve consulting, teaching, and research relationships with various medical device and pharmaceutical companies by the host and contributors, underscoring transparency in the discussion.<br /><br />Overall, the PRAGUE-25 trial informs clinical decision-making by comparing an interventional procedure with a comprehensive lifestyle and medication regimen, advancing understanding of personalized treatment strategies for atrial fibrillation patients. The session offered valuable expert perspectives on integrating these findings into practice to optimize patient outcomes.

Keywords

PRAGUE-25 trial

atrial fibrillation

catheter ablation

lifestyle modification

antiarrhythmic drugs

heart rhythm control

treatment strategies

clinical decision-making

procedure risks

patient outcomes