The Lead Episode 126: A Discussion of Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Premature Ventricular Contractions: A Crossover, Randomized Clinical Trial (NoVa-PVC)-A Discussion of Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Premature Ventricular Contractions: A Crossover, Randomized Clinical Trial (NoVa-PVC) (Speaker Information)

A Discussion of Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Premature Ventricular Contractions: A Crossover, Randomized Clinical Trial (NoVa-PVC) (Speaker Information)

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This document summarizes a clinical discussion on the study titled "Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Premature Ventricular Contractions: A Crossover, Randomized Clinical Trial (NoVa-PVC)," published in JACC: Clinical Electrophysiology. The trial investigated whether non-invasive vagus nerve stimulation (tVNS) could effectively reduce premature ventricular contractions (PVCs), common cardiac arrhythmias linked to adverse outcomes.<br /><br />The discussion was hosted by Dr. Sandeep A Saha of Oregon Heart Center and featured contributions from Dr. Arun R. Mahankali Sridhar of Pulse Heart Institute and Dr. Charles A. Henrikson of the OHSU Knight Cardiovascular Institute. The research team comprised multidisciplinary experts including Stefanos Zafeiropoulos MD, MBA, and Stavros Stavrakis PhD, MD, key figures in the study design and execution.<br /><br />This randomized crossover study evaluated the efficacy of tVNS to modulate autonomic tone as a therapeutic strategy to suppress PVCs without the need for invasive procedures or medications. The trial’s crossover design allowed participants to serve as their own controls, enhancing reliability of results. While the article’s detailed outcomes are not provided here, the clinical importance lies in exploring a novel, non-pharmacological approach to arrhythmia management.<br /><br />Disclosures note Dr. Henrikson’s consulting roles with the American College of Cardiology and Medtronic, while other contributors reported no conflicts of interest.<br /><br />In summary, this clinical trial and accompanying expert discussion highlight the potential of transcutaneous vagus nerve stimulation as a promising, minimally invasive treatment modality for PVC suppression, warranting further research to establish clinical protocols and long-term benefits.

Keywords

Transcutaneous Electrical Vagus Nerve Stimulation

Premature Ventricular Contractions

PVC suppression

Randomized Clinical Trial

Crossover study design

Non-invasive cardiac therapy

Autonomic tone modulation

Cardiac arrhythmia management

JACC Clinical Electrophysiology

Minimally invasive treatment