The Lead Episode 133: A Discussion of Feasibility and Safety of PFA for Coronary Sinus and Left Atrial Appendage Isolation and Mitral Isthmus Ablation Acute and Chronic Findings (LIVE at APHRS 2025)-The Lead Episode 133 Speaker and Article Information

The Lead Episode 133 Speaker and Article Information

Pdf Summary

This document summarizes a live discussion hosted by Dr. Michael S. Lloyd at APHRS 2025 on the feasibility and safety of pulsed field ablation (PFA) for coronary sinus and left atrial appendage isolation, as well as mitral isthmus ablation. The primary article under review, published in Circulation: Arrhythmia and Electrophysiology, features a study led by Dr. Vincenzo Mirco La Fazia and colleagues, examining both acute and chronic outcomes of PFA in these cardiac regions.<br /><br />The discussion involved expert contributors Dr. Rahul N Doshi and Dr. Kelvin C. Chua, alongside host Dr. Lloyd. They explored the clinical implications of PFA, an emerging non-thermal ablation technique, highlighting its procedural feasibility and safety profile in achieving targeted cardiac tissue isolation and ablation. The talk provided insights on procedural effectiveness and potential advantages over traditional thermal methods, with attention to the challenges and outcomes documented in the study.<br /><br />All physicians disclosed relevant relationships with medical technology companies, indicating their expertise and involvement in the field. Dr. Doshi and Dr. Lloyd reported consultancies and honoraria with leading cardiovascular device manufacturers.<br /><br />Overall, the session offered a contemporary expert perspective on PFA’s role in managing complex arrhythmias through coronary sinus and left atrial appendage isolation and mitral isthmus ablation, underscoring the technique’s promising safety and efficacy observed in acute and chronic patient follow-ups. This advancement represents a significant step in cardiac electrophysiology, with potential to improve procedural success and patient outcomes in arrhythmia treatment.

Keywords

pulsed field ablation

coronary sinus isolation

left atrial appendage isolation

mitral isthmus ablation

cardiac electrophysiology

arrhythmia treatment

non-thermal ablation

procedural safety

acute and chronic outcomes

clinical feasibility