The Lead Episode 159: A Discussion of Atrial Mechanical Contraction Predicts Cerebrovascular Risk in Patients With Transthyretin Amyloid Cardiomyopathy and Sinus Rhythm-The Lead Episode 159 Bonus Video File

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Video Summary

This episode discusses a study on transthyretin amyloid cardiomyopathy (ATTR) in patients who were in sinus rhythm. Using a large UK amyloidosis database, researchers found that left atrial mechanical dysfunction or atrial electromechanical dissociation was common and strongly linked to stroke/TIA risk and future atrial fibrillation, even without prior AF. Patients with no atrial contraction had about a threefold higher stroke risk. The hosts note that anticoagulation may not depend only on rhythm in ATTR, but more study is needed before changing practice. Better screening for AF and atrial function was suggested.

Keywords

transthyretin amyloid cardiomyopathy

left atrial mechanical dysfunction

atrial electromechanical dissociation

stroke risk

atrial fibrillation