The Lead Episode 171: A Discussion of the CMR Guide Trial-The Lead Episode 171 Speaker Information

The Lead Episode 171 Speaker Information

Pdf Summary

This document is a discussion introduction for the <strong>CMR GUIDE randomized clinical trial</strong>, hosted by <strong>Jason T. Jacobson, MD, FHRS</strong> with contributions from <strong>Jeanne E. Poole, MD</strong> and <strong>Sei Iwai, MD</strong>. The trial, published in the <strong>Journal of the American Medical Association</strong>, is titled <strong>“Cardiovascular Magnetic Resonance to Guide Defibrillator Implantation for LVEF of 36% to 50%.”</strong>

The study focuses on whether <strong>cardiovascular magnetic resonance (CMR)</strong> can help guide decisions about <strong>defibrillator implantation</strong> in patients with <strong>mild to moderate left ventricular systolic dysfunction</strong>, specifically those with <strong>left ventricular ejection fraction (LVEF) between 36% and 50%</strong>. This patient group is clinically important because their risk of sudden cardiac events may not be fully captured by LVEF alone, and more precise imaging could improve selection for device therapy.

The document also lists the article’s authors, including investigators from multiple institutions, and identifies the host and contributors for the discussion session.

A separate section provides <strong>disclosures</strong> for the presenters. Jason T. Jacobson reports honoraria, consulting, stock options, and research support from multiple medical companies and organizations. Jeanne E. Poole and Sei Iwai also disclose relevant consulting and speaking relationships.

Overall, the slide deck serves as an opening frame for a medical discussion of whether CMR can better stratify risk and improve defibrillator implantation decisions in patients with moderately reduced heart function.

Keywords

CMR GUIDE

randomized clinical trial

defibrillator implantation

cardiovascular magnetic resonance

left ventricular ejection fraction

LVEF 36% to 50%

mild to moderate systolic dysfunction

sudden cardiac events

risk stratification

JAMA article