The Lead Episode 20: A Discussion of (RAPID): A Multicentre, Randomised Trial-The Lead Episode 20 Speaker Information

The Lead Episode 20 Speaker Information

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The article titled "A Discussion of Self-Administered Intranasal Etripamil Using a Symptom-Promoted, Repeat-Dose Regimen for Atrioventricular-Modal-Dependent Supraventricular Tachycardia (RAPID): A Multicentre, Randomised Trial" was the topic of discussion hosted by Dr. William H. Sauer.<br /><br />The authors of the article are Bruce S Stambler, A John Camm, Marco Alings, Paul Dorian, Hein Heidbuchel, Jaco Houtgraaf, Peter R Kowey, Jose L Merino, Blandine Mondésert, Jonathan P Piccini, Sean D Pokorney, Philip T Sager, Atul Verma, J Marcus Wharton, David B Bharucha, Francis Plat, Silvia Shardonofsky, Michael Chen, and James E Ip.<br /><br />The discussion involved Dr. Sunil Kapur and Dr. David Chiang from Brigham and Women's Hospital. The article focuses on self-administered intranasal etripamil, a drug used for the treatment of atrioventricular-modular-dependent supraventricular tachycardia (SVT).<br /><br />SVT is a rapid heart rate condition that starts in the atria or atrioventricular node. The RAPID trial investigated the efficacy and safety of intranasal etripamil as a self-administered treatment option for SVT.<br /><br />The study involved a randomized, double-blind, placebo-controlled trial at multiple centers. The participants self-administered the drug when experiencing SVT symptoms. The primary endpoint was the conversion to normal sinus rhythm within 30 minutes of drug administration.<br /><br />The discussion provided insights into the mechanism of action of intranasal etripamil, the selection criteria for patients, adverse effects, and future directions in SVT treatment.<br /><br />The authors and contributors disclosed their financial relationships with various companies, including those related to the topic of discussion.<br /><br />Overall, this discussion shed light on the potential of self-administered intranasal etripamil as a convenient and effective treatment option for patients with atrioventricular-modular-dependent SVT.

Keywords

Self-administered intranasal etripamil

Symptom-promoted repeat-dose regimen

Atrioventricular-modal-dependent supraventricular tachycardia

RAPID trial

Multicentre randomized trial

Dr. William H. Sauer

Bruce S Stambler

A John Camm

Mechanism of action

SVT treatment