The Lead Episode 93: A Discussion of Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study-The Lead Episode 93 Speaker Information

The Lead Episode 93 Speaker Information

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The MANIFEST-17K study discussed the safety of pulsed field ablation (PFA) for treating over 17,000 patients with atrial fibrillation. The study is notable for its large scale and was hosted by Dr. William H. Sauer from Brigham and Women's Hospital. The discussion included contributions from Dr. Tobias Reichlin from University Hospital Basel, Switzerland, and Dr. Nikolas Nozica from Brigham and Women's Hospital.<br /><br />The extensive list of authors from various prestigious institutions underscores the collaborative effort involved in this research. This collaborative study aimed to provide comprehensive insights into the safety profile of PFA, which is an emerging technique touted for its precision and minimized risk compared to traditional ablation methods.<br /><br />The publication in Nature Medicine signifies its importance and impact within the medical community. The use of PFA in treating atrial fibrillation is considered groundbreaking because it offers a potential reduction in complications often associated with thermal ablation, due to its non-thermal mechanism.<br /><br />As disclosed, Dr. Sauer received honoraria and consulting fees from several medical device companies and has conducted research supported by Medtronic, which is crucial information for evaluating potential conflicts of interest. Dr. Reichlin and Dr. Nozica reported no disclosures, adding an objective perspective to the discussion.<br /><br />This study is highly relevant for clinicians and researchers interested in innovative treatment options for atrial fibrillation, emphasizing safety in the adaptation of new medical technologies. The findings are expected to inform future clinical practices and guidelines surrounding PFA.

Keywords

MANIFEST-17K

pulsed field ablation

atrial fibrillation

safety

Dr. William H. Sauer

Brigham and Women's Hospital

collaborative study

Nature Medicine

non-thermal mechanism

innovative treatment