Unbreak My Heart: Progress Towards Personalized Arrhythmia Treatment-Stem Cell-derived Biological Pacemakers to Treat Conduction System Disorders (Presenter: Eugenio Cingolani, MD)

Stem Cell-derived Biological Pacemakers to Treat Conduction System Disorders (Presenter: Eugenio Cingolani, MD)

Video Transcription

Video Summary

In this video, the speaker discusses the potential use of stem cell therapy to develop biological pacemakers as an alternative to current electronic pacemakers. The current therapies for arrhythmias, such as pharmacotherapy and catheter ablation, have limitations and complications. The speaker explores different approaches to developing biological pacemakers, including functional re-engineering, stem cell therapy, hybrid approaches, and somatic reprogramming. The focus is on somatic reprogramming, where embryonic transcription factors are used to reprogram cardiomyocytes into sinoatrial nodal cells. The speaker presents the results of studies conducted on animal models, showing that overexpression of the TBX18 transcription factor can lead to the creation of sinoatrial nodes and the improvement of heart function. The speaker also discusses the potential of using minimally invasive delivery systems for clinical application and highlights the importance of future research to determine the optimal biological agent, delivery system, and patient population for biological pacemakers.

Meta Tag

Lecture ID 15810

Location Room 213

Presenter Eugenio Cingolani, MD

Role Invited Speaker

Session Date and Time May 10, 2019 10:30 AM - 12:00 PM

Session Number S-053

Keywords

stem cell therapy

biological pacemakers

electronic pacemakers

arrhythmias

somatic reprogramming

TBX18 transcription factor