(FIT)-Module 1, Workshop 1: Electrocardiographic/Electrophysiologic Correlation-London Case 1 Answer

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Video Summary

The exercise stress test is effective in diagnosing long QT syndrome types 1 and 2, as it reveals prolonged QT intervals during exercise, particularly in early recovery. Type 1 (LQT1) is linked to KCNQ1 gene mutations affecting the KVLQT1 potassium channel, leading to prolonged QT intervals and potential arrhythmias at fast heart rates. Long QT type 2 (LQT2) involves KCNH2 mutations, often resulting in T-wave abnormalities. Nadolol is notably effective in preventing arrhythmias and sudden death in LQT1, surpassing other beta blockers, including in asymptomatic mutation carriers.

Keywords

exercise stress test

long QT syndrome

LQT1

LQT2

Nadolol