(FIT)-Module 1, Workshop 1: Electrocardiographic/Electrophysiologic Correlation-London Case 7 Answer

Video Transcription

Video Summary

Stefan experienced acquired long QT syndrome due to factors including hypokalemia and three antibiotics, resulting in a significantly prolonged QTC of over 800 milliseconds. After stopping the medications and normalizing potassium levels, his QTC was borderline at 450 milliseconds. Acquired long QT syndrome, affecting up to 2% of people, is caused by drugs binding to the HERG potassium channel, diminishing repolarization reserve. Unlike inherited long QT syndrome, it typically requires no genetic testing unless there's a family history or prolonged QT persists off medication. Stefan should avoid QT-prolonging drugs to prevent recurrence.

Keywords

Acquired Long QT Syndrome

Hypokalemia

HERG Potassium Channel

QTc Prolongation

QT-Prolonging Drugs