(FIT)-Module 1, Workshop 1: Electrocardiographic/Electrophysiologic Correlation-Tomaselli Case 11 Answer

Video Transcription

Video Summary

Delayed afterdepolarizations (DADs) are linked to intracellular calcium overload and leaky ryanodine receptors, potentially triggering action potentials. Factors like rapid rates, catecholamines, and digitalis predispose to DADs. The main cause is calcium release from intracellular stores. In contrast, early afterdepolarizations (EADs) are related to prolonged action potential duration, pause-dependent onset, and reactivation of sodium and calcium currents, often linked to polymorphic PT and torsade de pointes. The primary mechanism behind DADs involves calcium release from intracellular stores, making it the correct answer in this context.

Keywords

Delayed afterdepolarizations

Intracellular calcium overload

Leaky ryanodine receptors

Early afterdepolarizations

Action potential abnormalities