(FIT)-Module 1, Workshop 1: Electrocardiographic/Electrophysiologic Correlation-Tomaselli Case 12 Answer

Video Transcription

Video Summary

The video highlights the role of connexin 43 in heart failure, particularly its downregulation, which leads to slower conduction in the epicardium, evidenced by crowded isochrones in heart failure models. While other changes like potassium current downregulation and sodium-calcium exchanger alteration are observed, connexin 43's downregulation, including its altered subcellular localization, has a significant impact on ventricular myocardium conduction. The video concludes that among various factors influencing heart failure, connexin 43's downregulation is most prominent, important for understanding basic heart failure mechanisms.

Keywords

connexin 43

heart failure

downregulation

ventricular myocardium conduction

epicardium conduction slowing