(FIT)-Module 1, Workshop 1: Electrocardiographic/Electrophysiologic Correlation-Tomaselli Case 2 Answer

Video Transcription

Video Summary

The ECG reveals a type 1 Brugada pattern with coved ST-segment elevation and T-wave inversion in the right pericordial lead, primarily due to differences in the early action potential phase across the right ventricular wall. This is attributed to the larger transient outward potassium currents in the epicardium compared to the endocardium. While some Brugada syndrome patients have sodium channel mutations, these, along with calcium channel mutations, do not affect this gradient. Inward rectifier currents primarily influence the resting membrane potential and later action potential phases.

Keywords

Brugada pattern

ECG

ST-segment elevation

transient outward potassium currents

right ventricular wall