(FIT)-Module 1, Workshop 1: Electrocardiographic/Electrophysiologic Correlation-Tomaselli Case 3 Answer

Video Transcription

Video Summary

The video discusses digitalis-induced delayed after depolarizations, focusing on a case where a patient with dilated cardiomyopathy received ICD shocks due to tachycardia. Observations include bidirectional ventricular tachycardia, a hallmark of digitalis toxicity. Digitalis inhibits sodium-potassium ATPase, increasing intracellular calcium and sodium, which affects the sodium-calcium exchanger and can lead to arrhythmias. In therapeutic doses, it slows atrial and AV nodal conduction through parasympathetic effects; however, in toxic doses, it causes intracellular calcium overload, promoting delayed after depolarizations and arrhythmias like bidirectional tachycardia.

Keywords

digitalis toxicity

delayed after depolarizations

bidirectional ventricular tachycardia

dilated cardiomyopathy

sodium-potassium ATPase inhibition