(FIT)-Module 1, Workshop 1: Electrocardiographic/Electrophysiologic Correlation-Tomaselli Case 9 Question

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Video Summary

The question asks to explain the rate-dependent effects on conduction velocity and action potential duration at 80% recovery in ventricular cardiomyocytes. The given options are: synthetic activation of repolarizing currents, cumulative inactivation of delayed rectifier potassium currents, depletion of calcium, or cumulative inactivation of sodium current. Recorded data shows action potentials and conduction velocities at three different pacing cycles: 1,500, 1,000, and 500 milliseconds, providing insight into how these variables are influenced by pacing cycle length. The answer requires understanding how these physiological mechanisms affect cardiac action potential dynamics under different pacing conditions.

Keywords

rate-dependent effects

conduction velocity

action potential duration

ventricular cardiomyocytes

pacing cycle length