This session will explore changes in cardiac electrophysiology that occur with age, mechanisms underlying these changes, and how they may be targeted for novel anti-arrhythmic strategies.

• Describe age-related factors contributing to cardiac arrhythmias.
• Summarize pathophysiological changes in cardiac electrophysiology that occur with age.
• Explain potential anti-arrhythmic targets in the aging heart.

Emily Zeitler, MD, MHS
Stacey Rentschler, MD, PhD

Cardiac Frailty and Hormonal Changes as Age-related Anti-arrhythmic Targets
Presenter(s): Robert A. Rose, PhD

Impact of Genetics on Age-related Arrhythmia Susceptibility
Presenter(s): Carol Ann Remme

Age-related Structural and Functional Changes of the Intracardiac Nervous System
Presenter(s): Carlo de Asmundis, MD, PhD

Stress Kinases and Age-related Ventricular Arrhythmias
Presenter(s): Xun Ai, MD

Robert Rose:

• Nothing Relevant to Disclose

Carol Ann Remme:

• Nothing Relevant to Disclose

Carlo de Asmundis:

• AtriCure, Inc. (Honoraria/Speaking/Consulting Fee - Speaking and Teaching)

Xun Ai:

• Nothing Relevant to Disclose

To view all Heart Rhythm 2025 Faculty Disclosures, please click here.

General Concepts
   --   Pathophysiological Basis of Cardiac Arrhythmias and Basic EP
      --   4. Know abnormalities of cardiac electrophysiology, including altered ion channel function (inherited and drug-induced) and their effect on action potentials.

General Concepts
   --   Pathophysiological Basis of Cardiac Arrhythmias and Basic EP
      --   6. Know the mechanisms of cardiac arrhythmias including re-entry, triggered activity, and abnormal automaticity, as well as associated triggers such as ischemia, changes in autonomic tone, and drugs.

General Concepts
   --   Pathophysiological Basis of Cardiac Arrhythmias and Basic EP
      --   7. Know the systemic disorders, as well as metabolic and electrolyte abnormalities associated with arrhythmias and conduction abnormalities.